| Pair Name | Platycodin D, Venetoclax | ||
| Phytochemical Name | Platycodin D (PubChem CID: 162859 ) | ||
| Anticancer drug Name | Venetoclax (PubChem CID: 49846579 ) | ||
| Structure of Phytochemical |
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3D
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| Structure of Anticancer Drug |
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| Pair Name | Platycodin D, Venetoclax | |||
| Disease Info | [ICD-11: 2A60.Z] | Acute myeloid leukemia | Investigative | |
| Biological Phenomena | Induction-->Blockade of cell cycle in G0/G1 phase | |||
| Gene Regulation | Down-regulation | Phosphorylation | AKT1 | hsa207 |
| Up-regulation | Expression | BAK1 | hsa578 | |
| Up-regulation | Expression | BAX | hsa581 | |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Up-regulation | Expression | BCL-xL | hsa598 | |
| Up-regulation | Expression | BIM | hsa10018 | |
| Up-regulation | Cleavage | CASP3 | hsa836 | |
| Down-regulation | Expression | CYCS | hsa54205 | |
| Down-regulation | Phosphorylation | GSK3B | hsa2932 | |
| Down-regulation | Phosphorylation | MAPK1 | hsa5594 | |
| Up-regulation | Expression | MCL1 | hsa4170 | |
| Up-regulation | Cleavage | PARP1 | hsa142 | |
| Down-regulation | Phosphorylation | S6K1 | KEGG ID N.A. | |
| In Vitro Model | MV4-11 | Childhood acute monocytic leukemia | Homo sapiens (Human) | CVCL_0064 |
| THP-1 | Childhood acute monocytic leukemia | Homo sapiens (Human) | CVCL_0006 | |
| Result | Platycodin D may be a potent therapeutic candidate for the treatment of AML | |||
| No. | Title | Href |
|---|---|---|
| 1 | Platycodin D induces apoptotic cell death through PI3K/AKT and MAPK/ERK pathways and synergizes with venetoclax in acute myeloid leukemia. Eur J Pharmacol. 2023 Oct 5;956:175957. doi: 10.1016/j.ejphar.2023.175957. | Click |
